[Study on in vitro dissolution rate of geniposide in huangqin qingfei dispersible tablet].
Zhongguo Zhong Yao Za Zhi
; 28(8): 721-3, 2003 Aug.
Article
em Zh
| MEDLINE
| ID: mdl-15015350
ABSTRACT
OBJECTIVE:
To study in vitro dissolution rate of geniposide in Huangqin Qingfei dispersible tablet.METHOD:
A reversed-phase HPLC method was developed for determination of geniposide. In vitro dissolution rates were compared between Huangqin Qingfei dispersible tablet and conventional tablet in the dissolution medium of pH 1.0, 2.85, 4.5, 6.8, and 8.0 accordingly. Zero-class model, single-index model, logarithm normal school model, and Weibull distributing model were used to simulate the dissolution curve.RESULT:
The dissolution rate of two tablets is not affected by pH so much, and they can dissolve within 5 to 10 minutes. Weibull distributing model is the best simulation for in vitro dissolution. Comparing with conventional tablet, dispersible tablet dissolve quickly and completely.CONCLUSION:
The in vitro dissolution rate of geniposide in Huangqin Qingfei dispersible tablet conforms to Weibull distributing model. The dispersible tablet is able to release rapidly.
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Base de dados:
MEDLINE
Medicinas Tradicionais:
Medicinas_tradicionales_de_asia
/
Medicina_china
Métodos Terapêuticos e Terapias MTCI:
Terapias_biologicas
Assunto principal:
Plantas Medicinais
/
Piranos
/
Medicamentos de Ervas Chinesas
/
Gardenia
/
Iridoides
Tipo de estudo:
Prognostic_studies
Idioma:
Zh
Revista:
Zhongguo Zhong Yao Za Zhi
Ano de publicação:
2003
Tipo de documento:
Article