Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system.
Nat Neurosci
; 7(4): 335-6, 2004 Apr.
Article
em En
| MEDLINE
| ID: mdl-15034587
ABSTRACT
Hypothalamic pro-opiomelanocortin (POMC) neurons help regulate long-term energy stores. POMC neurons are also found in the nucleus tractus solitarius (NTS), a region regulating satiety. We show here that mouse brainstem NTS POMC neurons are activated by cholecystokinin (CCK) and feeding-induced satiety and that activation of the neuronal melanocortin-4 receptor (MC4-R) is required for CCK-induced suppression of feeding; the melanocortin system thus provides a potential substrate for integration of long-term adipostatic and short-term satiety signals.
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Base de dados:
MEDLINE
Medicinas Complementares:
Homeopatia
Assunto principal:
Resposta de Saciedade
/
Sincalida
/
Núcleo Solitário
/
Receptor Tipo 4 de Melanocortina
/
Ingestão de Alimentos
/
Hipotálamo
Idioma:
En
Revista:
Nat Neurosci
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Estados Unidos