Evaluation of hepatoprotective effects of Helminthostachys zeylanica (L.) Hook against carbon tetrachloride-induced liver damage in Wistar rats.
J Ethnopharmacol
; 92(1): 61-6, 2004 May.
Article
em En
| MEDLINE
| ID: mdl-15099849
ABSTRACT
The rhizomes of Helminthostachys zeylanica (L.) are used by the Kattunaikan tribe of Kerala, for the treatment of various hepatic disorders. In the present study, the effect of the methanolic extract of Helminthostachys zeylanica rhizomes on carbon tetrachloride (CCl4)-induced liver damage in Wistar rats was studied. The results showed that significant hepatoprotective effect was obtained against CCl4-induced liver damage, by oral administration of Helminthostachys zeylanica methanolic extract as evident from decreased levels of serum enzymes and an almost normal architecture of the liver, in the treated groups, compared to the controls. The extract was effective in increasing the choleretic activity of anaesthetised normal rats. It also shortened hexobarbitone-induced sleeping time in mice, which was increased by CCl4 treatment, besides showing significant antilipid peroxidant effect in vitro. Thus, the present study provides a scientific rationale for the traditional use of this plant in the management of liver diseases.
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Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Terapias_biologicas
Assunto principal:
Extratos Vegetais
/
Substâncias Protetoras
/
Gleiquênias
/
Doença Hepática Induzida por Substâncias e Drogas
/
Fígado
/
Fitoterapia
Tipo de estudo:
Etiology_studies
Idioma:
En
Revista:
J Ethnopharmacol
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Índia