Synthesis and biological evaluation of new inhibitors of UDP-Galf transferase--a key enzyme in M. tuberculosis cell wall biosynthesis.
Org Biomol Chem
; 2(17): 2418-20, 2004 Sep 07.
Article
em En
| MEDLINE
| ID: mdl-15326520
ABSTRACT
Two iminosugars have been designed and synthesized as potential inhibitors of UDP-Galf transferase, an enzyme involved in Mycobacterium tuberculosis cell wall biosynthesis. The design is based on a proposed model of the transition state for the transferase reaction. One of the two racemic compounds is the first reported inhibitor of the target enzyme from M. smegmatis.
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Base de dados:
MEDLINE
Assunto principal:
Inibidores Enzimáticos
/
Galactosiltransferases
/
Iminas
/
Mycobacterium tuberculosis
Idioma:
En
Revista:
Org Biomol Chem
Ano de publicação:
2004
Tipo de documento:
Article