Lipoxygenase inhibitory constituents from Periploca aphylla.
J Nat Prod
; 67(9): 1450-4, 2004 Sep.
Article
em En
| MEDLINE
| ID: mdl-15387640
ABSTRACT
Bisflavan-3-ols 1 and 2 and norterpenoid 3 have been isolated from the methanolic extract of the whole plant of Periploca aphylla. Their structures have been assigned on the basis of spectroscopic analysis including 1D and 2D NMR techniques. In addition, o-phthalic acid bis(2-ethylnonyl) ester (4), 1,3,6-trihydroxy-2,5-dimethoxyxanthone (5), and (+)-lyoniresinol (6) have been reported for the first time from this species. Compounds 1-3 displayed evident inhibitory potential against the enzyme lipoxygenase in a concentration-dependent fashion with IC(50) values 19.7, 13.5, and 150.1 microM, respectively.
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Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Terapias_biologicas
Assunto principal:
Plantas Medicinais
/
Terpenos
/
Flavonoides
/
Inibidores de Lipoxigenase
/
Cicloexanos
/
Periploca
País/Região como assunto:
Asia
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Paquistão