Dimethylglycine supplementation does not affect plasma homocysteine concentrations in pre-dialysis chronic renal failure patients.
Clin Biochem
; 37(11): 974-6, 2004 Nov.
Article
em En
| MEDLINE
| ID: mdl-15498524
ABSTRACT
OBJECTIVE:
To determine whether daily dimethylglycine supplementation affects plasma homocysteine concentrations. DESIGN ANDMETHODS:
A randomized, blinded, crossover design was used. Seven pre-dialysis chronic renal failure patients consumed 400 mg of dimethylglycine or placebo daily for 28 days. Fasting blood samples and 12-h urine samples were collected at baseline and at the end of each treatment period for analysis.RESULTS:
No significant differences were observed in plasma homocysteine (P = 0.624), glycine betaine (P = 0.452) and methionine (P = 0.457) concentrations between dimethylglycine and placebo treatments.CONCLUSION:
Daily supplementation with dimethylglycine does not affect plasma homocysteine.
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Base de dados:
MEDLINE
Assunto principal:
Sarcosina
/
Homocisteína
/
Falência Renal Crônica
Tipo de estudo:
Clinical_trials
Idioma:
En
Revista:
Clin Biochem
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Nova Zelândia