Clinical endocrinology and metabolism. Ghrelin, a novel growth-hormone-releasing and appetite-stimulating peptide from stomach.
Best Pract Res Clin Endocrinol Metab
; 18(4): 517-30, 2004 Dec.
Article
em En
| MEDLINE
| ID: mdl-15533773
ABSTRACT
Recent identification of novel appetite-regulating hormones has revealed the complex interactions of these humoral factors in the regulation of feeding behavior in mammals. One of these hormones, ghrelin, a natural ligand of the orphan receptor GHS-R, purified from stomach, is able to stimulate growth hormone release from pituitary cells. Ghrelin is a 28 amino acid peptide containing an n-octanoylated serine 3 residue that is essential for its activity. Ghrelin stimulates appetite by acting on the hypothalamic arcuate nucleus, the region known to control food intake. As an orexigenic peptide, ghrelin is therefore an endogenous regulator of feeding behavior from the peripheral tissues to the central nervous system.
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Base de dados:
MEDLINE
Assunto principal:
Apetite
/
Hormônio do Crescimento Humano
/
Hormônios Peptídicos
/
Mucosa Gástrica
/
Hormônios Gastrointestinais
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Best Pract Res Clin Endocrinol Metab
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Japão