Cone damage in patients receiving high-dose irofulven treatment.
Arch Ophthalmol
; 123(1): 29-34, 2005 Jan.
Article
em En
| MEDLINE
| ID: mdl-15642808
ABSTRACT
OBJECTIVES:
To describe the clinical, perimetric, and electroretinographic (ERG) results of 4 patients with cone dysfunction following irofulven treatment including the histopathologic and immunocytochemical features of one patient's retinas.DESIGN:
Observational case series.METHODS:
The patients were examined clinically, including perimetric and ERG evaluations. Eyes from patient 1 and healthy postmortem eyes were processed for histopathologic and immunocytochemistry studies with antibodies specific for cones, rods, and reactive Müller cells. MAIN OUTCOMEMEASURES:
Clinical signs and symptoms, perimetry, ERG, retinal histopathologic and immunocytochemistry study results.RESULTS:
All 4 patients had ERG changes consistent with abnormal cone responses and relatively normal rod responses. Compared with control eyes, the retina of patient 1 had approximately half the normal numbers of macular cones and fewer peripheral cones. The number of rods were normal but all rod and cone outer segments were shortened.CONCLUSION:
High-dose irofulven treatment causes cone-specific damage with relative sparing of rods.
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Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Terapias_biologicas
/
Aromoterapia
Assunto principal:
Doenças Retinianas
/
Sesquiterpenos
/
Células Fotorreceptoras Retinianas Cones
/
Antineoplásicos Alquilantes
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
Idioma:
En
Revista:
Arch Ophthalmol
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Estados Unidos