Hypocretin-1 (orexin A) deficiency in acute traumatic brain injury.
Neurology
; 65(1): 147-9, 2005 Jul 12.
Article
em En
| MEDLINE
| ID: mdl-16009905
ABSTRACT
Hypocretin-1 is involved in the regulation of the sleep-wake cycle. The authors prospectively assessed CSF hypocretin-1 levels in 44 consecutive patients with acute traumatic brain injury (TBI). Compared with controls, hypocretin-1 levels were abnormally lower in 95% of patients with moderate to severe TBI and in 97% of patients with posttraumatic brain CT changes. Hypocretin-1 deficiency after TBI may reflect hypothalamic damage and be linked with the frequent development of posttraumatic sleep-wake disorders.
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Base de dados:
MEDLINE
Assunto principal:
Transtornos do Sono-Vigília
/
Neuropeptídeos
/
Lesões Encefálicas
/
Peptídeos e Proteínas de Sinalização Intracelular
/
Doenças Hipotalâmicas
/
Hipotálamo
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Neurology
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
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