[Effects of silybin on acute myocardial infarction and reperfusion injury in anesthetized rats].
Zhongguo Yao Li Xue Bao
; 13(1): 69-71, 1992 Jan.
Article
em Zh
| MEDLINE
| ID: mdl-1605039
ABSTRACT
The effects of silybin (Sil) on myocardial infarction size and ischemia- and reperfusion-induced arrhythmias were studied in anesthetized open chest Sprague-Dawley rats. It was found that pretreatment with Sil 20, 50, and 80 mg.kg-1 iv reduced significantly infarct size by 34.7%, 35.0%, and 50.6% respectively at 4 h after ligation. Sil prevented ischemic arrhythmia only at the dose of 80 mg.kg-1. In reperfusion experiment, pretreatment with Sil 20 mg.kg-1 decreased significantly reperfusion-induced arrhythmia.
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Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Plantas_medicinales
Assunto principal:
Arritmias Cardíacas
/
Silimarina
/
Infarto do Miocárdio
Tipo de estudo:
Etiology_studies
Idioma:
Zh
Revista:
Zhongguo Yao Li Xue Bao
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
China