Synthesis and chemiluminescent high throughput screening for inhibition of acetylcholinesterase activity by imidazo[2,1-b]thiazole derivatives.
Eur J Med Chem
; 40(12): 1331-4, 2005 Dec.
Article
em En
| MEDLINE
| ID: mdl-16129518
ABSTRACT
The synthesis of a new series of imidazo[2,1-b]thiazole derivatives is described. They were tested as acetylcholinesterase inhibitors by means of a chemiluminescent method suitable for high throughput screening. The compounds without quaternization had no appreciable inhibitory potency probably because they are poorly soluble in water. The corresponding quaternized compounds were good inhibitors with activity related to the spacer employed.
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Base de dados:
MEDLINE
Assunto principal:
Acetilcolinesterase
/
Tiazóis
/
Imidazóis
/
Medições Luminescentes
Tipo de estudo:
Diagnostic_studies
/
Screening_studies
Idioma:
En
Revista:
Eur J Med Chem
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Itália