The effect of early recombinant erythropoietin and enteral iron supplementation on blood transfusion in preterm infants.
Am J Perinatol
; 22(8): 449-55, 2005 Nov.
Article
em En
| MEDLINE
| ID: mdl-16283605
ABSTRACT
Premature infants<1500 g were randomly assigned to study and control groups. In the study group, 42 premature infants received recombinant human erythropoietin (r-Hu EPO) 750 U/kg per week subcutaneously from day 5 to 40 and enteral iron supplementation of 2 to 6 mg/kg/d beginning on day 14 provided that they were receiving at least 50% energy intake orally. In the control group, 51 infants received the same dose of enteral iron supplementation beginning at the end of the fourth week. At the end of a 12-week monitoring period, r-Hu EPO combined with early enteral iron reduced transfusion needs only in the subgroup<1000 g. r-Hu EPO and early iron treatment had no effect on the development of severe retinopathy of prematurity, intraventricular hemorrhage, necrotizing enterocolitis, and bronchopulmonary dysplasia. We suggest that r-Hu EPO combined with early enteral iron is both effective and safe in infants<1000 g.
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Base de dados:
MEDLINE
Assunto principal:
Recém-Nascido Prematuro
/
Mortalidade Infantil
/
Eritropoetina
/
Anemia Neonatal
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Am J Perinatol
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Turquia