Antipyretic activity of Alstonia macrophylla Wall ex A. DC: an ethnomedicine of Andaman Islands.
J Pharm Pharm Sci
; 8(3): 558-64, 2005 Oct 06.
Article
em En
| MEDLINE
| ID: mdl-16401402
ABSTRACT
PURPOSE:
Alstonia macrophylla Wall ex A. DC. Leaf, used in different ailments by the Onge tribes of Little Andaman Island, India, was investigated for its antipyretic potential.METHODS:
The methanol extract and its fractions were tested on normal body temperature and yeast-induced pyrexia in Wistar Albino rats.RESULTS:
The leaf extract at oral doses of 200 and 300 mg/kg, and the n-butanol fractions of the extract at 50 mg/kg showed significant reduction in normal body temperature and yeast-provoked elevated temperature in a dose-dependent manner comparable to that of standard antipyretic drug paracetamol. The antipyretic effect was started at 1 h and extended for at least 5 h after the drug administration.CONCLUSIONS:
The antipyretic effect was more pronounced when the fraction A and B was administered together, indicating that both the fractions may contain antipyretic compounds which produce an additive effect in combination. Phytochemically these fractions contain beta-sitosterol and ursolic acid.
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Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Terapias_biologicas
Assunto principal:
Analgésicos não Narcóticos
/
Alstonia
/
Febre
/
Medicina Tradicional
País/Região como assunto:
Asia
Idioma:
En
Revista:
J Pharm Pharm Sci
Ano de publicação:
2005
Tipo de documento:
Article