Feasibility of using collagen as the base of the antifungal drug, miconazole.
J Oral Rehabil
; 33(5): 363-7, 2006 May.
Article
em En
| MEDLINE
| ID: mdl-16629895
ABSTRACT
The feasibility of using collagen as the base of miconazole was investigated. The addition of 33% collagen to a miconazole solution did not affect the minimal inhibitory concentration (MIC80) of the miconazole solution for Candida albicans. When 1 microg mL(-1) of miconazole in 33% collagen solution was plated on resin discs and dried to yield a thin membrane, the growth of C. albicans on the resin discs was nearly completely inhibited. In addition, we compared the antifungal effect of this collagen solution that contained 1 microg mL(-1) miconazole, with the antifungal effect of miconazole gel that had been diluted with glycerol (the main component of miconazole gel) to yield a final concentration of 1 microg mL(-1) of miconazole; as a result, we found that the collagen solution containing 1 microg mL(-1) miconazole had a stronger antifungal effect. In conclusion, our results demonstrated that it may be feasible to use collagen as the base of miconazole instead of glycerol, and suggest that a collagen-based miconazole solution would have a stronger antifungal effect than commercially available miconazole gel. Collagen-based miconazole solution may be useful for the treatment of Candida-associated denture stomatitis.
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Base de dados:
MEDLINE
Assunto principal:
Candida albicans
/
Portadores de Fármacos
/
Colágeno
/
Miconazol
/
Antifúngicos
Idioma:
En
Revista:
J Oral Rehabil
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Japão