Metabonomics techniques and applications to pharmaceutical research & development.
Pharm Res
; 23(6): 1075-88, 2006 Jun.
Article
em En
| MEDLINE
| ID: mdl-16715371
ABSTRACT
In this review, the background to the approach known as metabonomics is provided, giving a brief historical perspective and summarizing the analytical and statistical techniques used. Some of the major applications of metabonomics relevant to pharmaceutical Research & Development are then reviewed including the study of various influences on metabolism, such as diet, lifestyle, and other environmental factors. The applications of metabonomics in drug safety studies are explained with special reference to the aims and achievements of the Consortium for Metabonomic Toxicology. Next, the role that metabonomics might have in disease diagnosis and therapy monitoring is provided with some examples, and the concept of pharmacometabonomics as a way of predicting an individual's response to treatment is highlighted. Some discussion is given on the strengths and weaknesses, opportunities of, and threats to metabonomics.
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Base de dados:
MEDLINE
Assunto principal:
Farmacologia
/
Farmacocinética
/
Tecnologia Farmacêutica
/
Biologia de Sistemas
/
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Pharm Res
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Reino Unido