Thalamic sensory relay nucleus stimulation for the treatment of peripheral deafferentation pain.
Stereotact Funct Neurosurg
; 84(4): 180-3, 2006.
Article
em En
| MEDLINE
| ID: mdl-16905881
ABSTRACT
We applied chronic deep brain stimulation (DBS) of the thalamic nucleus ventralis caudalis (Vc) for the treatment of peripheral deafferentation pain. The subjects included 11 cases of phantom limb pain and 7 of root or nerve injury pain without phantom sensation. In the phantom limb pain patients, the spike density markedly increased in the same area of the Vc where microstimulation induced paresthesia in the part with phantom sensation. Reorganization of the receptive field representation within the Vc was also demonstrated by microrecording and microstimulation. In the root or nerve injury pain patients with severe allodynia and without phantom sensation, oscillating neural hyperactivity appeared when the allodynia was induced during single-cell recording in the Vc. In both groups stimulation of these areas with the DBS electrode was useful for achieving pain reduction. Inhibition of spinothalamic tract neurons, restoration of the original receptive field representation and modulation of thalamocortical rhythmic oscillations are proposed to play important roles in a possible mechanism of Vc-DBS for the treatment of deafferentation pain.
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Base de dados:
MEDLINE
Assunto principal:
Membro Fantasma
/
Tálamo
/
Causalgia
/
Estimulação Encefálica Profunda
Idioma:
En
Revista:
Stereotact Funct Neurosurg
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Japão