Solid-phase synthesis of a combinatorial library of dihydroceramide analogues and its activity in human alveolar epithelial cells.
Bioorg Med Chem
; 15(1): 50-62, 2007 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-17081760
ABSTRACT
Solid-phase synthesis of a small combinatorial library of dihydroceramide analogues as mixtures of erythro and threo diastereomers is described. Some dihydroceramide analogues cause growth arrest and apoptosis in a dose-dependent manner in human alveolar epithelial cells. This activity is likely due to the threo isomers, as evidenced by cellular studies with a pair of diastereomerically pure N-acyldihydrosphingosines. The apoptotic activity reported in this work provides information for the design of new compounds that may provide the basis for the generation of biochemical tools for the study of different pathologies where ceramide and/or dihydroceramide are involved.
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Base de dados:
MEDLINE
Assunto principal:
Ceramidas
/
Técnicas de Química Combinatória
/
Células Epiteliais
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
Bioorg Med Chem
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Espanha