Hyperbaric oxygen and bone marrow-derived endothelial progenitor cells in diabetic wound healing.
Vascular
; 14(6): 328-37, 2006.
Article
em En
| MEDLINE
| ID: mdl-17150153
ABSTRACT
Endothelial progenitor cells (EPCs) are the key cellular effectors of postnatal vasculogenesis and play a central role in wound healing. In diabetes, there is a significant impairment in the number and function of circulating and wound-tissue EPC. Recent evidence indicates, that tissue-level hyperoxia achieved by therapeutic hyperbaric oxygen protocols (HBO2) can increase the mobilization of EPC from the bone marrow into peripheral blood. In this paper we review the recent reports on hyperoxia-mediated mobilization of bone marrow-derived EPC and postulate avenues of future research in this area as it applies to improving healing in chronic wounds affected by diabetes and peripheral arterial disease (PAD).
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Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Terapias_biologicas
/
Oxigenoterapia_hiperbrica
Assunto principal:
Cicatrização
/
Células da Medula Óssea
/
Pé Diabético
/
Neovascularização Fisiológica
/
Células Endoteliais
/
Diabetes Mellitus
/
Oxigenoterapia Hiperbárica
Tipo de estudo:
Guideline
Idioma:
En
Revista:
Vascular
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Estados Unidos