Omeprazole reduces the response to capsaicin but not to methacholine in asthmatic patients with proximal reflux.
Scand J Gastroenterol
; 42(3): 299-307, 2007 Mar.
Article
em En
| MEDLINE
| ID: mdl-17354108
ABSTRACT
OBJECTIVE:
To study the relationships between airway responsiveness to methacholine and capsaicin, proximal or distal reflux and the effects of short-term acid inhibition. MATERIAL ANDMETHODS:
Twenty-nine asthmatics, not taking steroids regularly, underwent respiratory symptom measurements, 24-h dual-probe pH monitoring, and challenges with methacholine and capsaicin. Challenges and symptom measurements were repeated after 12 days' omeprazole treatment (20 mg b.i.d.). The results (median and range) were expressed as PD20 methacholine (mg) and PD5 capsaicin (dose causing five coughs, nmol).RESULTS:
Seventeen patients presented pathological reflux in the distal esophagus, and 17 in the proximal esophagus. At baseline no correlation was found between PD20 or PD5 and reflux. Treatment with omeprazole did not change bronchial responsiveness to methacholine (basal 0.16 mg, 0.02-1.27; omeprazole 0.15 mg, 0.02-1.60); omeprazole decreased the tussive response to capsaicin (basal 0.08 nmol, 0.08-2.46; omeprazole 0.61 nmol, 0.08-9.84, p<0.001) only in patients with pathological reflux. The decrease was positively correlated with proximal acid exposure (r2=0.70, p<0.001). Omeprazole reduced asthma symptoms in patients with proximal reflux, cough in those with proximal or distal reflux.CONCLUSIONS:
In asthmatics, inhibition of gastric acid secretion does not influence bronchial hyperresponsiveness but decreases tussive sensitivity and this effect is related to proximal reflux.
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Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Plantas_medicinales
Assunto principal:
Asma
/
Omeprazol
/
Capsaicina
/
Refluxo Gastroesofágico
/
Broncoconstritores
/
Cloreto de Metacolina
/
Analgésicos não Narcóticos
/
Antiulcerosos
Tipo de estudo:
Etiology_studies
Idioma:
En
Revista:
Scand J Gastroenterol
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Itália