Weight gain reduction in mice fed Panax ginseng saponin, a pancreatic lipase inhibitor.
J Agric Food Chem
; 55(8): 2824-8, 2007 Apr 18.
Article
em En
| MEDLINE
| ID: mdl-17367157
ABSTRACT
Roots of the herb Panax ginseng are known to contain high levels of bioactive saponins. Here, we isolated saponins from ginseng root powder and studied their inhibitory effect on the absorption of dietary fat in male Balb/c mice. Consumption of ginseng saponins suppressed the expected increase in body weight and plasma triacylglycerols, following a high-fat diet and observed higher intake. Consumption of ginseng saponins had no effect on the concentration of the total plasma cholesterol in both chow and high-fat diets in mice. The mode by which saponins from ginseng inhibit lipid metabolism was assessed as the in vitro inhibition of pancreatic lipase. Ginseng saponin inhibited pancreatic lipase with an apparent IC50 value of 500 mug/mL. Our results suggest that the anti-obesity and hypolipidemic effects of Ginseng in high-fat diet-treated mice were attributed to the isolated saponin fraction. These metabolic effects of the ginseng saponins may be mediated by inhibition of pancreatic lipase activity.
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Base de dados:
MEDLINE
Assunto principal:
Pâncreas
/
Saponinas
/
Aumento de Peso
/
Inibidores Enzimáticos
/
Panax
/
Lipase
Idioma:
En
Revista:
J Agric Food Chem
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Israel