Cytotoxic activity of some natural and synthetic ent-kauranes.
J Nat Prod
; 70(3): 347-52, 2007 Mar.
Article
em En
| MEDLINE
| ID: mdl-17378530
ABSTRACT
Atractyligenin (1) and several synthetic derivatives were tested and found to be active against tumor cell replication. Compound 1 was readily converted to the 2,15-diketo (3) or 15-keto (4) derivatives, which contain an alpha,beta-unsaturated ketone. Compounds 3 and 4 showed significant cytotoxic activity against all six tested cancer cell lines and were most potent against 1A9 ovarian cancer cells with EC50 values of 0.2 and 0.3 microM, respectively. These two 1-analogues are promising lead compounds for further investigation.
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Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Terapias_biologicas
Assunto principal:
Atractilosídeo
/
Diterpenos do Tipo Caurano
/
Antineoplásicos Fitogênicos
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Itália