Effect of genioglossus contraction on pharyngeal lumen and airflow in sleep apnoea patients.
Eur Respir J
; 30(4): 748-58, 2007 Oct.
Article
em En
| MEDLINE
| ID: mdl-17567673
ABSTRACT
The purpose of the present study was to quantify the mechanical effect of genioglossus stimulation on flow mechanics and pharyngeal cross-sectional area in patients with obstructive sleep apnoea, and to identify variables that determine the magnitude of the respiratory effect of tongue protrusion. The pressure/flow and pressure/cross-sectional area relationships of the velo- and oropharynx were assessed in spontaneously breathing propofol-anaesthetised subjects before and during genioglossus stimulation. Genioglossus contraction decreased the critical pressure significantly from 1.2+/-3.3 to -0.7+/-3.8 cmH(2)O, with individual decreases ranging -0.6-5.9 cmH(2)O. Pharyngeal compliance was not affected by genioglossus contraction. The pharyngeal response to genioglossus stimulation was related to the magnitude of advancement of the posterior side of the tongue, but not to the severity of sleep apnoea, critical pressure, compliance or the shape and other characteristics of the velopharynx. Genioglossus contraction enlarges both the velo- and the oropharynx and lowers the critical pressure without affecting pharyngeal stiffness. The response to genioglossus stimulation depends upon the magnitude of tongue protrusion achieved rather than on inherent characteristics of the patient and their airway.
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Base de dados:
MEDLINE
Assunto principal:
Faringe
/
Apneia Obstrutiva do Sono
/
Nervo Hipoglosso
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Eur Respir J
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Israel