Hypothermia in VGKC antibody-associated limbic encephalitis.
J Neurol Neurosurg Psychiatry
; 79(2): 202-4, 2008 Feb.
Article
em En
| MEDLINE
| ID: mdl-18202210
ABSTRACT
Voltage-gated potassium channel antibody (VGKC-Ab)-associated limbic encephalitis (LE) is a recently described syndrome that broadens the spectrum of immunotherapy-responsive central nervous system disorders. Limbic encephalitis is typically characterised by a sub-acute onset of disorientation, amnesia and seizures, but the clinical spectrum is not yet fully defined and the syndrome could be under-diagnosed. We here describe the clinical profile of four patients with VGKC-Ab-associated LE who had intermittent, episodic hypothermia. One of the patients also described a prodrome of severe neuropathic pain preceding the development of limbic symptoms. Both of these novel symptoms responded well to immunosuppressive therapy, with concurrent amelioration of amnesia/seizures.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
/
Encefalite Límbica
/
Canais de Potássio de Abertura Dependente da Tensão da Membrana
/
Hipotermia
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Risk_factors_studies
Idioma:
En
Revista:
J Neurol Neurosurg Psychiatry
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Reino Unido