Effects of Radix scutellariae and Rhizoma atractylodis on LPS-induced abortion and the uterine IL-10 contents in mice.
Am J Chin Med
; 36(1): 141-8, 2008.
Article
em En
| MEDLINE
| ID: mdl-18306457
ABSTRACT
In the present study, lipopolysaccharide (LPS) was injected i.v. via the tail vein (0.1 microg per mouse) to induce abortion (embryo resorption) in Kunming mice. The interleukin 10 (IL-10) contents in the uterus were assayed by ELISA. The results revealed that the IL-10 level was significantly decreased in the LPS-induced abortion group of mice compared to the controls. Use of Pentoxifylline (PXF), or a combination of Radix scutellariae and Rhizoma atractylodis reversed the LPS effects bringing down the fetal resorption rate, and increasing the IL-10 level significantly. The study indicates that the anti-abortive effects of PXF and the combination of Radix scutellariae and Rhizoma atractylodis are closely related to up-regulation of the Th2 cytokine IL-10 at the maternal fetal interface.
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Base de dados:
MEDLINE
Assunto principal:
Útero
/
Abortivos
/
Extratos Vegetais
/
Lipopolissacarídeos
/
Aborto Induzido
/
Interleucina-10
/
Araceae
/
Ranunculaceae
Idioma:
En
Revista:
Am J Chin Med
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
China