Radioprotection of whole-body gamma-irradiation-induced alteration in some haematological parameters by cysteine, vitamin E and their combination in rats.
Strahlenther Onkol
; 167(8): 498-501, 1991 Aug.
Article
em En
| MEDLINE
| ID: mdl-1887368
ABSTRACT
Radioprotective effect of cysteine, vitamin E and their combination on gamma-irradiation-induced alteration in some haematological parameters in male rats has been studied 24 and 48 hrs after whole-body gamma-irradiation at a dose level of 7.5 Gy. The results of this study reveal that gamma-irradiation caused a significant decrease in red blood cells (RBCs) count with insignificant change in hemoglobin level, 24 and 48 hrs postirradiation, gamma-irradiated rats showed as well a progressive decrease in their blood ATP, and serum-SH levels with a significant increase in blood glutathione (GSH) level. Administration of cysteine or vitamin E preceding gamma-radiation exposure gave a significant radioprotection to the above haematological parameters. However, combination of both agents afforded a better protection, so that most of the measured parameters were restored to the pre-irradiated values. Finally, the date demonstrate that the radioprotection provided by combined administration of vitamin E and cysteine is feasible and perhaps, even more efficient against radiation injury to RBCs. This will appreciate the usage of such combination in protecting the patient during radiotherapy.
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Base de dados:
MEDLINE
Assunto principal:
Protetores contra Radiação
/
Vitamina E
/
Sangue
/
Irradiação Corporal Total
/
Cisteína
Idioma:
En
Revista:
Strahlenther Onkol
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
Egito