Studies on the analgesic, anti-inflammatory and antipyretic effects of Parquetina nigrescens leaf extract.
J Ethnopharmacol
; 122(1): 86-90, 2009 Feb 25.
Article
em En
| MEDLINE
| ID: mdl-19111918
ETHNOPHARMACOLOGICAL RELEVANCE: Parquetina nigrescens is a shrub that is commonly used in different parts of West Africa for the treatment of several ailments which includes pain, fever and inflammatory conditions. AIM OF THE STUDY: The present study was designed to investigate the analgesic, anti-inflammatory and antipyretic effects of the aqueous extract of Parquetina nigrescens leaves in rats. MATERIALS AND METHODS: Five groups were used for each study, groups 1 and 5 served as control (saline) and reference (indomethacine) respectively, while groups 2-4 received the extract (50-200 mg/kg) orally. Formalin paw licking and hot plate latency tests were used for analgesic studies. Carrageenan oedema, cotton pellet granuloma and formaldehyde arthritis models were used to quantify the anti-inflammatory activities while the brewer's yeast was used for inducing pyrexia. RESULTS: The results of the analgesic study show that the extract produced significant (p<0.05) analgesia in the hot plate and in the formalin tests. In the anti-inflammatory study, Parquetina nigrescens produced significant (p<0.05) inhibition of the various types of inflammation. The extract also inhibited the pyrexia induced by brewer's yeast. CONCLUSION: The result justifies the traditional uses of Parquetina nigrescens for the treatment of fever, inflammatory and painful conditions.
Texto completo:
1
Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Terapias_biologicas
Assunto principal:
Dor
/
Extratos Vegetais
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Analgésicos não Narcóticos
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Apocynaceae
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Febre
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Analgésicos
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Anti-Inflamatórios
Idioma:
En
Revista:
J Ethnopharmacol
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Nigéria