The growth inhibition of Streptococcus mutans by 5'-nucleotidase inhibitors from Areca catechu L.
Chem Pharm Bull (Tokyo)
; 39(5): 1323-4, 1991 May.
Article
em En
| MEDLINE
| ID: mdl-1914009
ABSTRACT
New 5'-nucleotidase inhibitors named NF-86I, NF-86II were recently isolated from the seeds of Areca catechu L. NF-86I and NF86II showed inhibitory effects on the growth of Streptococcus mutans MT8148(c) and Streptococcus mutans MT6715(g), respectively. In addition, these inhibitors could inhibit insoluble glucan formation from sucrose. NF-86I and NF-86II were found to be polyphenolic substances. Some polyphenols such as tannic acid bind non-specifically to proteins (tannic activity). The 5'-nucleotidase inhibitors that we isolated did not show any such activity. However, the growth inhibitory activity and the inhibitory effect on water-insoluble glucan production were equal to tannic acid. It is therefore considered that these inhibitors bind specifically to the bacterial cell surface. Our findings suggest that the 5'-nucleotidase inhibitors NF-86I and NF-86II may be useful anti-plaque preventing agents.
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Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Terapias_biologicas
Assunto principal:
Areca
/
Plantas Medicinais
/
Streptococcus mutans
/
Flavonoides
/
5'-Nucleotidase
Idioma:
En
Revista:
Chem Pharm Bull (Tokyo)
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
Japão