[Effect of Patrinia scabra extracts on the level of serum cytokine in sarcoma 180 ascitic tumor burdened mice].
Zhong Yao Cai
; 31(11): 1689-91, 2008 Nov.
Article
em Zh
| MEDLINE
| ID: mdl-19260282
ABSTRACT
OBJECTIVE:
To explore the effect of Potrinia scabro extracts (PSE) on the level of serum cytokine in Sarcoma 180 ascitic tumor burdened mice and its mechanism of anti-tumor.METHODS:
The mice model of Sarcoma 180 ascitic tumor were established and divided into five groups randomly, including the model group with normal saline solution, the positive group with 10 mg/kg cytoxan and PSE treated groups at doses of 2.0 g/kg, 1.0 g/kg, 0.5 g/kg intraperitoneally for 10 days. The level of serum cytokine Th1 (IL-2, IL-12, IFN-gamma, IFN-alpha) and Th2 (IL-6, IL-10) were measured by double antibody sandwich ELISA assay.RESULTS:
Compared with model group of Sarcoma 180 ascitic tumor burdened mice,the level of IL-2 and IFN-gamma increased in PSE 2.0 g/kg group, but the IL-6 and IL-10 decreased in PSE 2.0 g/kg and 1.0 mg/kg groups.CONCLUSION:
PSE has anti-tumor effect in vivo that could be related to the level variation of IL-2, IFN-gamma, IL-6 and IL-10 in tumor burdened mice.
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Base de dados:
MEDLINE
Assunto principal:
Sarcoma 180
/
Extratos Vegetais
/
Citocinas
/
Cucurbitaceae
/
Antineoplásicos Fitogênicos
Tipo de estudo:
Prognostic_studies
Idioma:
Zh
Revista:
Zhong Yao Cai
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
China