Fasting-induced intestinal damage is mediated by oxidative and inflammatory responses.
Br J Surg
; 96(5): 552-9, 2009 May.
Article
em En
| MEDLINE
| ID: mdl-19358174
ABSTRACT
BACKGROUND:
Green tea has been shown to repair fasting-induced mucosal damage in rat intestine. The aim of this study was to elucidate the underlying mechanism.METHODS:
Five groups of rats were used. Group 1 had free access to chow diet and water, and those in group 2 were fasted for 3 days. Animals in group 3 were fasted for 3 days, then were allowed drinking water for a further 7 days. Groups 4 and 5 were fasted for 3 days, then given drinking water containing green tea or vitamin E respectively for 7 days. Blood was collected for estimation of total plasma antioxidants, and jejunal samples were used for immunohistochemical analysis of superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx), and for estimation of myeloperoxidase (MPO) activity.RESULTS:
Use of green tea was associated with a significant increase in total plasma antioxidants (P < 0.001), and mucosal SOD (P < 0.001), catalase (P = 0.006) and GPx (P = 0.017), but a significant decrease in MPO activity (P < 0.001). Vitamin E produced similar changes, but the effects were smaller.CONCLUSION:
Green tea reverses the fasting-induced damage to the intestinal mucosa by its antioxidant and anti-inflammatory effect.
Texto completo:
1
Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Terapias_biologicas
/
Plantas_medicinales
Assunto principal:
Chá
/
Jejum
/
Peroxidase
/
Preparações de Plantas
/
Enterite
/
Doenças do Jejuno
/
Antioxidantes
Idioma:
En
Revista:
Br J Surg
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Kuait