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Stable form of galectin-9, a Tim-3 ligand, inhibits contact hypersensitivity and psoriatic reactions: a potent therapeutic tool for Th1- and/or Th17-mediated skin inflammation.
Niwa, Haruna; Satoh, Takahiro; Matsushima, Yuki; Hosoya, Kazuki; Saeki, Kazumi; Niki, Toshiro; Hirashima, Mitsuomi; Yokozeki, Hiroo.
Afiliação
  • Niwa H; Department of Dermatology, Graduate School, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan.
Clin Immunol ; 132(2): 184-94, 2009 Aug.
Article em En | MEDLINE | ID: mdl-19464955
ABSTRACT
Tim-3 is a cell surface molecule preferentially expressed in Th1 and Th17 cells. Galectin-9 is a ligand for Tim-3 and the binding of galectin-9 to Tim-3 induces apoptosis. We recently developed a stable form of galectin-9 (sGal-9) by partial deletion of the linker peptide. In this study, we characterized the therapeutic effects of sGal-9 on inflammatory reactions in contact hypersensitivity and IL-23-induced psoriatic mouse models. In contact hypersensitivity in mice, the ear swelling response was suppressed by sGal-9. In vitro treatment with sGal-9 resulted in cell apoptosis of CD4, CD8, and hepatic NK cells. sGal-9-treated mice had decreased IFN-gamma- and IL-17-producing T cells. Similarly, sGal-9 reduced epidermal thickness and dermal cellular infiltrate levels in IL-23-induced psoriasis-like skin inflammation. This was accompanied by decreased skin lesion levels of IL-17 and IL-22. sGal-9 may be a unique and useful therapeutic tool for the treatment of Th1- and/or Th17-mediated skin inflammation.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Métodos Terapêuticos e Terapias MTCI: Terapias_biologicas Assunto principal: Psoríase / Pele / Galectinas / Dermatite de Contato Tipo de estudo: Etiology_studies / Prognostic_studies Idioma: En Revista: Clin Immunol Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Japão

Texto completo: 1 Base de dados: MEDLINE Métodos Terapêuticos e Terapias MTCI: Terapias_biologicas Assunto principal: Psoríase / Pele / Galectinas / Dermatite de Contato Tipo de estudo: Etiology_studies / Prognostic_studies Idioma: En Revista: Clin Immunol Ano de publicação: 2009 Tipo de documento: Article País de afiliação: Japão