Photodynamic therapy for head and neck dysplasia and cancer.
Arch Otolaryngol Head Neck Surg
; 135(8): 784-8, 2009 Aug.
Article
em En
| MEDLINE
| ID: mdl-19687399
ABSTRACT
OBJECTIVE:
To determine the response of dysplasia, carcinoma in situ (CIS), and T1 carcinoma of the oral cavity and larynx to photodynamic therapy with porfimer sodium.DESIGN:
Prospective trial.SETTING:
A National Cancer Institute-designated cancer institute. PATIENTS Patients with primary or recurrent moderate to severe oral or laryngeal dysplasia, CIS, or T1N0 carcinoma. INTERVENTION Porfimer sodium, 2 mg/kg of body weight, was injected intravenously 48 hours before treatment. Light at 630 nm for photosensitizer activation was delivered from an argon laser or diode laser using lens or cylindrical diffuser fibers. The light dose was 50 J/cm(2) for dysplasia and CIS and 75 J/cm(2) for carcinoma. MAIN OUTCOMEMEASURES:
Response was evaluated at 1 week and at 1 month and then at 3-month intervals thereafter. Response options were complete (CR), partial (PR), and no (NR) response. Posttreatment biopsies were performed in all patients with persistent and recurrent visible lesions.RESULTS:
Thirty patients were enrolled, and 26 were evaluable. Mean follow-up was 15 months (range, 7-52 months). Twenty-four patients had a CR, 1 had a PR, and 1 had NR. Three patients with oral dysplasia with an initial CR experienced recurrence in the treatment field. All the patients with NR, a PR, or recurrence after an initial CR underwent salvage treatment. Temporary morbidities included edema, pain, hoarseness, and skin phototoxicity.CONCLUSION:
Photodynamic therapy with porfimer sodium is an effective treatment alternative, with no permanent sequelae, for oral and laryngeal dysplasia and early carcinoma. TRIAL REGISTRATION clinicaltrials.gov Identifier NCT00530088.
Texto completo:
1
Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Terapias_energeticas
Assunto principal:
Fotoquimioterapia
/
Lesões Pré-Cancerosas
/
Carcinoma in Situ
/
Fármacos Fotossensibilizantes
/
Éter de Diematoporfirina
/
Terapia com Luz de Baixa Intensidade
/
Neoplasias de Cabeça e Pescoço
Tipo de estudo:
Observational_studies
Idioma:
En
Revista:
Arch Otolaryngol Head Neck Surg
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos