Natural product leads for drug discovery: isolation, synthesis and biological evaluation of 6-cyano-5-methoxyindolo[2,3-a]carbazole based ligands as antibacterial agents.
Bioorg Med Chem
; 17(20): 7126-30, 2009 Oct 15.
Article
em En
| MEDLINE
| ID: mdl-19783449
ABSTRACT
Indolo[2,3-a]carbazole based inhibitors were synthesized from readily available indigo via a seven-step linear synthetic sequence with a moderate overall yield. The inhibitors were selectively and readily functionalized at the nitrogen on the indole portion of the carbazole unit. The synthesized analogs displayed moderate inhibitory activities toward Bacillus anthracis and Mycobacterium tuberculosis, indicating that indolo[2,3-a]carbazoles could serve as promising leads in the development of new drugs to combat anthrax and tuberculosis infections.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Produtos Biológicos
/
Carbazóis
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Descoberta de Drogas
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Antibacterianos
Idioma:
En
Revista:
Bioorg Med Chem
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos