Role of ethanol in kava hepatotoxicity.
Phytother Res
; 24(4): 475-80, 2010 Apr.
Article
em En
| MEDLINE
| ID: mdl-19943335
ABSTRACT
Kava is known for its recreational, ceremonial and medicinal use in the Pacific. The aqueous non-alcoholic drink of kava rhizome produces intoxicating, relaxing and soothing effects. While kava's medicinal effects receive worldwide recognition, kava-containing products came under scrutiny after over 100 reports of spontaneous adverse hepatic effects. Many mechanisms have been postulated to explain the unexpected toxicity, one being pharmacokinetic interactions between kavalactones and co-administered drugs involving cytochrome P450 enzyme system. Alcohol is often co-injested in kava hepatotoxicity cases. This review evaluates the possible hepatotoxicity mechanisms involving alcohol and kava.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Kava
/
Etanol
/
Doença Hepática Induzida por Substâncias e Drogas
Idioma:
En
Revista:
Phytother Res
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Austrália