Phenolic glycosides from Dodecadenia grandiflora and their glucose-6-phosphatase inhibitory activity.
Fitoterapia
; 81(6): 475-9, 2010 Sep.
Article
em En
| MEDLINE
| ID: mdl-20079814
ABSTRACT
Phytochemical investigation of Dodecadenia grandiflora leaves led to the isolation and identification of three phenolic glycosides, designated 1-[(4'-O-(E)-p-coumaroyl)-beta-D-glucopyranosyl]-oxy-2-phenol (1), 1-[(6'-O-(E)-p-coumaroyl)-beta-D-glucopyranosyl]-oxy-2-phenol (2) and 1-[O-beta-D-glucopyranosyl(1-->2)-beta-D-glucopyranosyl]-oxy-2-phenol (3), along with nine known compounds. Compounds 1, 2, 5 and 9 exhibited significant glucose-6-phosphatase inhibitory activity (63.7, 66.9, 82.9 and 85.4%) with IC(50) values of 88.5, 81.0, 51 and 50 microM respectively. On the basis of biological results, a structure-activity relationship has been discussed.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fenóis
/
Glucose-6-Fosfatase
/
Lauraceae
/
Glicosídeos
Idioma:
En
Revista:
Fitoterapia
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Índia