Dehydroepiandrosterone to enhance physical performance: myth and reality.
Endocrinol Metab Clin North Am
; 39(1): 127-39, x, 2010 Mar.
Article
em En
| MEDLINE
| ID: mdl-20122454
ABSTRACT
Dehydroepiandrosterone (DHEA) is secreted by the zona reticularis of the adrenal cortex and is converted into potent sex steroids in peripheral target cells. As oral DHEA administration can lead to dose-dependent increases in circulating androgens, which may reach high supraphysiologic levels in women, it has been included in the list of prohibited substances by the World Anti-Doping Agency (WADA). However, evidence for an ergogenic activity of DHEA is still largely nonexistent. Randomized trials in elderly subjects with an age-dependent decrease in DHEA have provided little or no evidence for enhanced physical performance after long-term administration of DHEA, 50 mg/d, and smaller short-term studies in healthy male athletes using higher doses were completely negative. Thus the widely perceived performance-enhancing activity of DHEA is still more myth than reality. However, because studies in female athletes are still lacking, an ergogenic activity of high-dose DHEA in this population cannot be excluded but is expected to be associated with adverse events like hirsutism, acne, and alopecia.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Desidroepiandrosterona
/
Dopagem Esportivo
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Desempenho Atlético
Tipo de estudo:
Clinical_trials
/
Prognostic_studies
Idioma:
En
Revista:
Endocrinol Metab Clin North Am
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Alemanha