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The impact of an aromatase inhibitor on body composition and gonadal hormone levels in women with breast cancer.
van Londen, G J; Perera, S; Vujevich, K; Rastogi, P; Lembersky, B; Brufsky, A; Vogel, V; Greenspan, S L.
Afiliação
  • van Londen GJ; Medicine, University of Pittsburgh, Kaufmann Medical Bldg, Pittsburgh, PA, 15213, USA. vanLondenJ@upmc.edu
Breast Cancer Res Treat ; 125(2): 441-6, 2011 Jan.
Article em En | MEDLINE | ID: mdl-21046232
Aromatase inhibitors (AIs) have become the standard adjuvant therapy of postmenopausal breast cancer survivors. AIs induce a reduction of bioavailable estrogens by inhibiting aromatase, which would be expected to induce alterations in body composition, more extensive than induced by menopause. The objectives are to examine the impact of AIs on (1) DXA-scan derived body composition and (2) gonadal hormone levels. This is a sub-analysis of a 2-year double-blind, placebo-controlled, randomized trial of 82 women with nonmetastatic breast cancer, newly menopausal following chemotherapy, who were randomized to risedronate (35 mg once weekly) versus placebo, and stratified for their usage of AI versus no AI. Outcomes included DXA-scan derived body composition and gonadal hormone levels. As a group, total body mass increased in women over 24 months. Women on AIs gained a significant amount of lean body mass compared to baseline as well as to no-AI users (P < 0.05). Women not on an AI gained total body fat compared to baseline and AI users (P < 0.05). Free testosterone significantly increased and sex hormone binding globulin (SHBG) significantly decreased in women on AIs compared to no AIs at 24 months (P < 0.01) while total estradiol and testosterone levels remained stable. Independent of AI usage, chemotherapy-induced postmenopausal breast cancer patients demonstrated an increase of total body mass. AI users demonstrated maintenance of total body fat, an increase in lean body mass and free testosterone levels, and a decrease in SHBG levels compared to no-AI users. The mechanisms and implications of these changes need to be studied further.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Composição Corporal / Índice de Massa Corporal / Densidade Óssea / Hormônios Gonadais / Inibidores da Aromatase Tipo de estudo: Clinical_trials Idioma: En Revista: Breast Cancer Res Treat Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Composição Corporal / Índice de Massa Corporal / Densidade Óssea / Hormônios Gonadais / Inibidores da Aromatase Tipo de estudo: Clinical_trials Idioma: En Revista: Breast Cancer Res Treat Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Estados Unidos