Chemical constituents from fruits of Harrisonia perforata.
Phytochemistry
; 72(6): 508-13, 2011 Apr.
Article
em En
| MEDLINE
| ID: mdl-21315383
ABSTRACT
Eight limonoids (1-8) including three A, B and D-seco-16-nor-type ones, 5,6-dehydrodesepoxyharperforin C2 (1), harrpernoid B (2), and its C-9S epimer, harrpernoid C (3), along with six known compounds (9-14), were isolated from fruits of Harrisonia perforata. Extensive spectroscopic analysis was used to elucidate their structures and stereochemistries. Further confirmation of structures of 1 and 2 were obtained by single-crystal X-ray diffraction. Limonoids (1-8) were evaluated for their anti-tobacco mosaic virus activity and in vitro cytotoxicity against A549 and HL60 cell lines; only compound 2 showed weak activity.
Texto completo:
1
Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Terapias_biologicas
Assunto principal:
Antivirais
/
Vírus do Mosaico do Tabaco
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Simaroubaceae
/
Limoninas
/
Frutas
/
Antineoplásicos
Idioma:
En
Revista:
Phytochemistry
Ano de publicação:
2011
Tipo de documento:
Article