Select screening in a specific high-risk population of patients suggests a stage migration toward detection of non-muscle-invasive bladder cancer.
Eur Urol
; 59(6): 1026-31, 2011 Jun.
Article
em En
| MEDLINE
| ID: mdl-21458152
ABSTRACT
BACKGROUND:
More than 25% of bladder cancer (BC) cases are still muscle-invasive at first diagnosis. Screening is unproven to enable the detection of more non-muscle-invasive tumors. BC association with aristolochic acid nephropathy (AAN) was reported after intake of slimming pills containing Chinese herbs.OBJECTIVE:
We evaluated whether a BC screening protocol in a high-risk and unique patient population had an impact on the stage of tumor presentation. DESIGN, SETTING, ANDPARTICIPANTS:
Forty-eight AAN-affected patients were enrolled in a screening program, establishing BC incidence during prospective screening cystoscopies and biopsies biannually for up to 10 yr. Two patients were lost to follow-up, and three refused screening after consenting. MEASUREMENTS Patients were evaluated for presence of BC and tumor stage at diagnosis. RESULTS ANDLIMITATIONS:
BC was diagnosed in 25 patients (52%). Among 43 patients who underwent screening cystoscopies (median follow-up 94 mo), 22 were first diagnosed with non-muscle-invasive BC but none with muscle-invasive tumors and none died of BC. Three women who declined follow-up were diagnosed and died with advanced metastatic disease. The limitations of our findings include the small sample size of this case series, the absence of a real control group, and the particular risk factor in these patients that differs from the usual risk factors, such as smoking or industrial chemicals.CONCLUSIONS:
BC screening in high-risk groups may allow identification of tumors before muscle invasion. The optimal screening schedule and the relevance of the present findings in smoking-related BC remain to be defined.
Texto completo:
1
Base de dados:
MEDLINE
Medicinas Tradicionais:
Medicinas_tradicionales_de_asia
/
Medicina_china
Assunto principal:
Neoplasias da Bexiga Urinária
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Medicamentos de Ervas Chinesas
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Programas de Rastreamento
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Fármacos Antiobesidade
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Cistoscopia
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Ácidos Aristolóquicos
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Nefropatias
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Guideline
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Prognostic_studies
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Risk_factors_studies
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Screening_studies
Idioma:
En
Revista:
Eur Urol
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Canadá