The role of carnitine in preventing renal damage developed as a result of infrarenal aortic ischemia-reperfusion.
Ren Fail
; 33(4): 440-9, 2011.
Article
em En
| MEDLINE
| ID: mdl-21529274
ABSTRACT
BACKGROUND:
This study was designed to use carnitine for preventing deposition of end products of lipid peroxidation in rat models in the prevention of ischemia-reperfusion (IR) damage frequently seen following operations of infrarenal abdominal aorta (AA).METHODS:
Forty male rats of Sprague-Dawley type were evenly (n = 8) randomized to five groups sham laparotomy (SHAM), carnitine control (CC), aortic IR (AIR), AIR + low-dose carnitine (AIR+LDC), and AIR + high-dose carnitine (AIR+HDC).RESULTS:
Compared to other groups, serum creatinine levels of AIR group were significantly higher. Also tissue malondialdehyde (MDA) levels of AIR group were significantly higher compared to SHAM, CC, and AIR+HDC groups. In histopathological examination, although tubular necrosis atrophy and tubular degeneration observed in AIR group showed regression with low-dose carnitine, tubular necrosis atrophy, tubular degeneration, glomerular damage, and vascular congestion thrombosis decreased with high-dose carnitine. Total score of histological damage was significantly higher in AIR, AIR+LDC, and AIR+HDC groups compared to SHAM and CC groups. Moreover, total score of histological damage was significantly lower in AIR+HDC group than AIR+LDC group.CONCLUSIONS:
In this study, we showed carnitine can partially prevent renal damage in infrarenal AIR models of rats. This result may open new prospects to us in the prevention of renal IR damage during surgery of aorta.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Aorta Abdominal
/
Complexo Vitamínico B
/
Carnitina
/
Traumatismo por Reperfusão
/
Injúria Renal Aguda
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Ren Fail
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Turquia