Grey matter and social functioning correlates of glutamatergic metabolite loss in schizophrenia.
Br J Psychiatry
; 198(6): 448-56, 2011 Jun.
Article
em En
| MEDLINE
| ID: mdl-21628707
ABSTRACT
BACKGROUND:
Thalamic glutamine loss and grey matter reduction suggest neurodegeneration in first-episode schizophrenia, but the duration is unknown.AIMS:
To observe glutamine and glutamate levels, grey matter volumes and social functioning in patients with schizophrenia followed to 80 months after diagnosis.METHOD:
Grey matter volumes and proton magnetic resonance spectroscopy metabolites in left anterior cingulate and left thalamus were measured in 17 patients with schizophrenia before medication and 10 and 80 months after diagnosis. Social functioning was assessed with the Life Skills Profile Rating Scale (LSPRS) at 80 months.RESULTS:
The sum of thalamic glutamate and glutamine levels decreased over 80 months, and correlated inversely with the LSPRS. Thalamic glutamine and grey matter loss were significantly correlated in frontal, parietal, temporal and limbic regions.CONCLUSIONS:
Brain metabolite loss is correlated with deteriorated social functioning and grey matter losses in schizophrenia, consistent with neurodegeneration.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
Tálamo
/
Ácido Glutâmico
/
Participação Social
/
Glutamina
/
Giro do Cíngulo
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Idioma:
En
Revista:
Br J Psychiatry
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Canadá