Effect of long-term PUVA treatment of psoriasis on the collagen and elastin gene expression and growth of skin fibroblasts in vitro.
Br J Dermatol
; 123(5): 621-30, 1990 Nov.
Article
em En
| MEDLINE
| ID: mdl-2174252
ABSTRACT
The proliferation rate, collagen metabolism and collagen and elastin messenger-RNA levels were studied in fibroblasts derived from patients who had received many courses of either systemic 8-methoxypsoralen or topical trioxsalen PUVA treatment. The proliferation rate of fibroblasts as measured by the incorporation of 3H-thymidine or by cellular division was decreased in those obtained from patients who had PUVA treatment as compared with controls. Collagen synthesis was slightly increased in the cells from PUVA-treated patients, but the relative collagen synthesis and the ratio between types I and III collagen were unchanged. The levels of collagen and elastin mRNAs were increased in fibroblasts derived from the PUVA-treated patients. No significant differences in histology or immunochemistry could be found in the biopsies taken from topical and systemic PUVA-treated patients.
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Base de dados:
MEDLINE
Assunto principal:
Psoríase
/
Terapia PUVA
/
RNA Mensageiro
/
Colágeno
/
Elastina
Idioma:
En
Revista:
Br J Dermatol
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
Finlândia