Prevention of seizure-induced sudden death in a chronic SUDEP model by semichronic administration of a selective serotonin reuptake inhibitor.
Epilepsy Behav
; 22(2): 186-90, 2011 Oct.
Article
em En
| MEDLINE
| ID: mdl-21783426
ABSTRACT
DBA/1 mice are a chronically susceptible model of sudden unexpected death in epilepsy (SUDEP) that exhibit chronic audiogenic generalized convulsive seizures (GCSs), leading to death from respiratory arrest (RA) if not resuscitated. Serotonin (5-HT) normally enhances respiration in response to elevated CO(2) levels, which occur during GCSs in humans. Selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine, increase 5-HT availability. We examined whether fluoxetine can block GCS-induced sudden death in DBA/1 mice. Fluoxetine (15-70 mg/kg ip) was administered acutely with seizure induction at 30minutes or semichronically in five daily doses (20mg/kg/day) with induction after 5 days. Acute fluoxetine (45 or 70 mg/kg) significantly reduced the incidence of RA without blocking seizure susceptibility. Semichronic fluoxetine did not block seizures, but significantly reduced seizure-induced RA, which is consistent with effects of SSRIs on respiration in patients with epilepsy [Bateman LM, Li DS,LiN TC, Seyal M. Epilepsia 2010;512211-4]. These findings suggest that treatment with SSRIs should be evaluated for reducing the incidence of SUDEP in patients.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Convulsões
/
Fluoxetina
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Inibidores Seletivos de Recaptação de Serotonina
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Morte Súbita
Tipo de estudo:
Etiology_studies
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Prognostic_studies
Idioma:
En
Revista:
Epilepsy Behav
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos