Vitamin D status affects strength gains in older adults supplemented with a combination of ß-hydroxy-ß-methylbutyrate, arginine, and lysine: a cohort study.
JPEN J Parenter Enteral Nutr
; 35(6): 757-62, 2011 Nov.
Article
em En
| MEDLINE
| ID: mdl-21807930
ABSTRACT
BACKGROUND:
Older adults supplemented for 1 year with ß-hydroxy-ß-methylbutyrate, arginine, and lysine (HMB/ARG/LYS) were previously shown to have significant gains in fat-free mass (FFM) but not muscular strength.OBJECTIVE:
Recently, increasing levels of serum vitamin D have been associated with an increase in muscle function, particularly in the elderly. To determine if vitamin D status may have limited strength gain in participants supplemented with HMB/ARG/LYS, the authors performed post hoc analysis of strength based on the participants' vitamin D status.METHODS:
Elderly (age 76.0 ± 1.6 years) adults were recruited for a double-blinded, controlled study and were randomly assigned to either an isonitrogenous control (n = 37) or HMB/ARG/LYS (n = 40) for the yearlong study. Participants were further segregated based on their vitamin D status of either <30 or ≥30 ng 25OH-vitD(3)/mL serum, and an analysis was performed on the 4 cohorts.RESULTS:
Regardless of vitamin D status, HMB/ARG/LYS resulted in significantly increased FFM (P < .02), but only in those with vitamin D status ≥30 ng 25OH-vitD(3)/mL was there a significant increase in strength with HMB/ARG/LYS (P < .01). Control-supplemented participants, regardless of vitamin D status, and the HMB/ARG/LYS-supplemented participants with vitamin D status <30 ng 25OH-vitD(3) failed to show improvements in strength.CONCLUSIONS:
The nutrient cocktail of HMB/ARG/LYS alone was effective in increasing muscle mass regardless of vitamin D status, but accompanying strength increases were observed only when participants also had adequate vitamin D status indicating a synergistic effect between the HMB/ARG/LYS and vitamin D.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vitamina D
/
Deficiência de Vitamina D
/
Butiratos
/
Aptidão Física
/
Músculo Esquelético
/
Força Muscular
/
Aminoácidos
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Idioma:
En
Revista:
JPEN J Parenter Enteral Nutr
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos