Royal jelly protects against ultraviolet B-induced photoaging in human skin fibroblasts via enhancing collagen production.
J Med Food
; 14(9): 899-906, 2011 Sep.
Article
em En
| MEDLINE
| ID: mdl-21812645
ABSTRACT
Royal jelly (RJ) is a honeybee product containing proteins, carbohydrates, fats, free amino acids, vitamins, and minerals. As its principal unsaturated fatty acid, RJ contains 10-hydroxy-2-decenoic acid (10-HDA), which may have antitumor and antibacterial activity and a capacity to stimulate collagen production. RJ has attracted interest in various parts of the world for its pharmacological properties. However, the effects of RJ on ultraviolet (UV)-induced photoaging of the skin have not been reported. In this study we measured the 10-HDA content of RJ by high-performance liquid chromatography and tested the effects of RJ on UVB-induced skin photoaging in normal human dermal fibroblasts. The effects of RJ and 10-HDA on UVB-induced photoaging were tested by measuring procollagen type I, transforming growth factor (TGF)-ß1, and matrix metalloproteinase (MMP)-1 after UVB irradiation. The RJ contained about 0.211% 10-HDA. The UVB-irradiated human skin fibroblasts treated with RJ and 10-HDA had increased procollagen type I and TGF-ß1 productions, but the level of MMP-1 was not changed. Thus RJ may potentially protect the skin from UVB-induced photoaging by enhancing collagen production.
Texto completo:
1
Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Terapias_biologicas
/
Apiterapia
Assunto principal:
Pele
/
Protetores Solares
/
Envelhecimento da Pele
/
Regulação para Cima
/
Colágeno Tipo I
/
Ácidos Graxos
País/Região como assunto:
Asia
Idioma:
En
Revista:
J Med Food
Ano de publicação:
2011
Tipo de documento:
Article