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Antioxidant and anti-apoptotic effects of onion (Allium cepa) extract on doxorubicin-induced cardiotoxicity in rats.
Alpsoy, Seref; Aktas, Cevat; Uygur, Ramazan; Topcu, Birol; Kanter, Mehmet; Erboga, Mustafa; Karakaya, Osman; Gedikbasi, Asuman.
Afiliação
  • Alpsoy S; Department of Cardiology, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey.
J Appl Toxicol ; 33(3): 202-8, 2013 Mar.
Article em En | MEDLINE | ID: mdl-21996788
The aim of this study was to investigate the antioxidant and anti-apoptotic effects of onion (Allium cepa) extracts (ACE) on doxorubicin (DOX)-induced cardiotoxicity. The rats in the ACE-pretreated group were given a daily dose of 1 ml ACE for 14 days. To induce cardiotoxicity, DOX (30 mg kg(-1) body weight) was injected intraperitoneally by a single dose and the rats were sacrificed after 48 h. To date, no such studies have been performed on the cardioprotective and anti-apoptotic potential of ACE on DOX-induced cardiotoxicity. Our data indicate a significant reduction in the activity of in situ identification of apoptosis using terminal dUTP nick end-labeling in cardiomyocytes of the DOX-treated group with ACE therapy. The DOX-treated with ACE groups showed a significant decrease in malondialdehyde levels, and increased activities of superoxide dismutase, glutathione and glutathione peroxidase in comparison with the DOX-treated group. Creatine kinase, creatine kinase MB, lactate dehydrogenase activities and cardiac troponin I levels were significantly decreased in the DOX + ACE group in comparison with the DOX group. These biochemical and histological disturbances were effectively attenuated on pretreatment with ACE. The present study showed that ACE may be a suitable cardioprotector against toxic effects of DOX.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Medicinas Complementares: Homeopatia Assunto principal: Extratos Vegetais / Doxorrubicina / Apoptose / Cebolas / Cardiopatias / Antibióticos Antineoplásicos / Antioxidantes Idioma: En Revista: J Appl Toxicol Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Turquia

Texto completo: 1 Base de dados: MEDLINE Medicinas Complementares: Homeopatia Assunto principal: Extratos Vegetais / Doxorrubicina / Apoptose / Cebolas / Cardiopatias / Antibióticos Antineoplásicos / Antioxidantes Idioma: En Revista: J Appl Toxicol Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Turquia