Methodological optimization of tinnitus assessment using prepulse inhibition of the acoustic startle reflex.
Brain Res
; 1485: 54-62, 2012 Nov 16.
Article
em En
| MEDLINE
| ID: mdl-22513102
ABSTRACT
Recently prepulse inhibition of the acoustic startle reflex (ASR) became a popular technique for tinnitus assessment in laboratory animals. This method confers a significant advantage over the previously used time-consuming behavioral approaches utilizing basic mechanisms of conditioning. Although this technique has been successfully used to assess tinnitus in different laboratory animals, many of the finer details of this methodology have not been described enough to be replicated, but are critical for tinnitus assessment. Here we provide detail description of key procedures and methodological issues that provide guidance for newcomers with the process of learning to correctly apply gap detection techniques for tinnitus assessment in laboratory animals. The major categories of these issues include refinement of hardware for best performance, optimization of stimulus parameters, behavioral considerations, and identification of optimal strategies for data analysis. This article is part of a Special Issue entitled Tinnitus Neuroscience.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Reflexo de Sobressalto
/
Zumbido
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Estimulação Acústica
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Brain Res
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos