Leiomyoma: genetics, assisted reproduction, pregnancy and therapeutic advances.
J Assist Reprod Genet
; 29(8): 703-12, 2012 Aug.
Article
em En
| MEDLINE
| ID: mdl-22584729
ABSTRACT
PURPOSE:
Uterine leiomyomas are common, benign, reproductive tract tumors affecting a majority of reproductive aged women. They are associated with gynecologic morbidity and detrimentally affect reproductive potential. The etiology of leiomyomas is poorly understood and their diagnosis prior to treatment with Assisted Reproductive Technologies (ART) represents a management dilemma. The purpose of this paper is to review known genetic and molecular contributions to the etiologies of leiomyomas, describe their impact on ART outcomes and reproductive potential, and review alternative therapies and future directions in management.METHODS:
A critical review of the literature pertaining to genetic component of uterine leiomyomas, their impact on ART and pregnancy and leiomyoma therapeutics was performed.RESULTS:
Uterine leiomyomas are characterized by complex molecular mechanisms. Their location and size determines their potential detriment to ART and reproductive function and novel therapeutic modalities are being developed.CONCLUSION:
The high prevalence of uterine leiomyomas and their potential detrimental influence on ART and reproductive function warrants continued well-designed studies to ascertain their etiology, optimal treatment and novel less morbid therapies.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Técnicas de Reprodução Assistida
/
Leiomioma
Tipo de estudo:
Etiology_studies
/
Prevalence_studies
/
Risk_factors_studies
Idioma:
En
Revista:
J Assist Reprod Genet
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos