Alterations in in vitro functional activities of alveolar macrophages exposed in vivo to mineral dusts.
Vet Hum Toxicol
; 32(6): 517-20, 1990 Dec.
Article
em En
| MEDLINE
| ID: mdl-2264257
ABSTRACT
To determine whether macrophages exposed to mineral dusts are altered, rats were exposed intratracheally to one of several mineral dusts, held 8 days, their lungs washed and the cellular composition of the fluid characterized morphologically and functionally. The number of cells recovered from lung washings of exposed rats increased 2 to 5 times relative to control rats; however, the percentage of such cells that were macrophages, or were capable of phagocytosis, adherence to glass or metabolism of carbohydrates via the hexose monophosphate shunt as indicated by reduction of nitroblue tetrazolium, were reduced. Silica dust produced the greatest effect, corresponding qualitatively to earlier in vivo studies.
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Base de dados:
MEDLINE
Assunto principal:
Fagocitose
/
Alvéolos Pulmonares
/
Macrófagos
/
Minerais
Idioma:
En
Revista:
Vet Hum Toxicol
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
Índia