Change in total body water as a predictive tool for growth hormone treatment response.
Horm Res Paediatr
; 78(1): 18-23, 2012.
Article
em En
| MEDLINE
| ID: mdl-22814191
ABSTRACT
BACKGROUND/AIMS:
To investigate whether short-term changes in body composition as a result of growth hormone therapy could be used to predict its growth effect after 1 year in children with growth hormone deficiency (GHD) and children born small for gestational age (SGA).METHODS:
88 GHD children and 99 SGA children who started treatment with recombinant human growth hormone were included. Total body water (TBW) and height were measured. After 1 year, patients were divided into adequate and inadequate responders.RESULTS:
In GHD and SGA children a sensitivity of 87 and 53%, respectively, and a specificity of 58 and 83%, respectively, were found. The positive predictive values for GHD and SGA children were 73 and 90%, respectively. The negative predictive values were 75 and 32%, respectively.CONCLUSION:
Changes in body composition data measured by TBW are a valuable tool to correctly predict 75% of the GHD children and are only useful in SGA children when the change in TBW is above the cut-off value of 0.7 l/m(2).
Texto completo:
1
Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Terapias_biologicas
/
Hidroterapia
Assunto principal:
Água Corporal
/
Recém-Nascido Pequeno para a Idade Gestacional
/
Hormônio do Crescimento Humano
/
Biomarcadores Farmacológicos
/
Transtornos do Crescimento
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Horm Res Paediatr
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Holanda