Adjuvants in influenza vaccines.
Vaccine
; 30(52): 7658-61, 2012 Dec 14.
Article
em En
| MEDLINE
| ID: mdl-23084848
ABSTRACT
The effectiveness of influenza vaccines is still controversial, and the role of adjuvants in such vaccines is briefly reviewed in this paper. Inactivated whole virus vaccines may include components that function as adjuvants, meaning that additive adjuvants are often not required. MF59 and AS03 showed higher adjuvanticity than aluminum salts in several clinical studies. Recent research has suggested that immune cell recruitment is the main mechanism underlying adjuvant actions in general, and that aluminum salts induce this recruitment via inflammation at the injected site. The aspect of how oil-based adjuvants, such as MF59 and AS03, recruit immune cells remains to be clarified.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vacinas contra Influenza
/
Adjuvantes Imunológicos
Idioma:
En
Revista:
Vaccine
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Japão